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Treating wrinkles and indentations in your face from the source Restore your skin's elasticity and glow. REGENERATIVE MEDICINE Treating wrinkles and indentations in your face from the source Restore your skin's elasticity and glow. REGENERATIVE MEDICINE

This treatment is a regenerative medicine that is available only in Japan,
in which Fibroblast growth factors (FGF), a medical growth factor, is added to one's
own growth factor extracted from blood and injected into the skin.
By regenerating the skin in the injected area, dark circles under the eyes and nasolabial folds
can be improved, and forehead can be rounded. There are many other adaptation
for various areas, so please check out our Instagram.
For Dark Circles Under The Eyes, sloping forehead, lines and more Skin Rejuvenate Injections For Dark Circles Under The Eyes, sloping forehead, lines and more Skin Rejuvenate Injections
  • Skin Rejuvenate Injections 01Skin Rejuvenate Injections 01

    Case Study42 year old Female

    Symptoms Dark circles under the eyes
    Injected area Under the eyes
  • Skin Rejuvenate Injections 02

    Case Study28 year old Female

    Symptoms Nasolabial fold
    Injected area Nasolabial fold
  • Skin Rejuvenate Injections 03Skin Rejuvenate Injections 03

    Case Study28 year old Female

    Symptoms Dent in forehead
    Injected area Forehead
Instagram Instagram
What is Skin Rejuvenate Injections and Microneeding skin treatment ? What is Skin Rejuvenate Injections and Microneeding skin treatment ?

Regeneration of skin cells using
the body's own blood

"Available only in Japan." PRPG injections is a skin regeneration treatment appled to cosmetic medicine that utelizes Platelet Rich Plasma(PRP) from the patient's own blood. Platelets contain high levels of natural growth factors, which activate various cells to regenerate and repair the tissue. A small amount of Fibroblast growth factors (FGF) for medical treatment is added to maximize the effect of Platelet-Derived Growth Factor.

Drawing Blood > Growth Factor Extraction > Injections Into the Skin Drawing Blood > Growth Factor Extraction > Injections Into the Skin
About PRP used in PRPG injection About PRP used in PRPG injection

The PRP used in "Available only in Japan." PRPG injection is extracted using a special centrifugal separation method developed by the clinic president who has studied for over 10 years to maximize the level of
Platelet-Derived Growth Factor. A small amount of Fibroblast growth factors (FGF) for medical treatment is added to stabilize the rejuvenative effect regardless of the patient's age or body composition.

Applicable to any body parts.

The regeneration effect of "Available only in Japan." PRPG injections can improve any type of skin problem, from improving dents to increasing volume.

Improvable facial symptoms
  • Dark circles under the eyes
  • Indentations above the eyes
  • Wrinkles between the eyebrows
  • Wrinkles on forehead
  • Wrinkles around the eyes
  • Mid cheek groove
  • Indentations in the cheeks
  • Marionette lines
  • Acne scars, Pores of the skin
Applicable to any body parts.

The regeneration effect of "Available only in Japan." PRPG Injection can improve any type of skin problem, from improving dents to increasing volume.

Improvable body symptoms
  • Aging hands
  • Wrinkles on the neck
  • Skin symtoms after a liposuction treatment
Applicable to any body parts.

The regeneration effect of "Available only in Japan." PRPG Injection can improve any type of skin problem, from improving dents to increasing volume.

Volume restorative treatment areas
  • Forehead
  • Temple
  • lips
  • Chin
  • bust
  • Hips
Available 24 hours a day Available 24 hours a day

Inquiry &
Free counseling service

  • Online reservation
  • Instagram
Why Skin Rejuvenate Injections and Microneeding Skin Treatment are so effective Why Skin Rejuvenate Injections and Microneeding Skin Treatment are so effective
  • Point1
    Obtained a patent in the United StatesSpecializing in regenerative medicine
  • Point2
    Afluent therapeutic experience.
  • Point3
    Regeneration with
    high effect and a long duration
  • Point4
    Authorized by the Ministry of Health,
    Labor and Welfare
  • Point4
    High safety and pain control
  • Obtained a patent in the United States & Specializing in regenerative medicine

    Obtained a patent in the United States &
    Specializing in
    regenerative
    medicine

    Pruge Beauty Clinic President, Shinichi Okamoto,MD.,PhD., has been researching regenerative treatment using prp since 2010, when PRP was not yet known to the general public. A study was published in the international journal of tissue regeneration engineering, Tissue Engineering.
    In addition, the Act has been granted a special permit in the United States. We specialize in regenerative medicine and are thoroughly particular about our PRP creation techniques. Those are the reasons why we proudly recommend our Skin Rejuvenate Injections.

  • The Skin Regeneration Effect Lasts more than 3 years!

    Afluent therapeutic experience.

    The Skin Regeneration Effect Lasts more than 3 years!

    We have performed over 15,000 treatments using PRPG in total. Since the results of PRPG treatment vary greatly depending on doctor's skill, it can be performed by our doctors with extensive experience and advanced design skills. Our doctors share an ideal result with the patients and completely customize the treatment to suit each patient's face and fulfill their wishes.

  • Obtained a patent in the United States & Specializing in regenerative medicine

    Highly Effective Skin Regeneration and Long Lasting Effect

    The PRP for "Available only in Japan."
     PRPG injection is extremely concentrated!

    Here at Pruge Beauty Clinic, we have succeeded in raising the concentration used, said to have an upper limit of about 3 times, by our original centrifugal separation technology to an ultra-high concentration of up to 30 times.

    Growth factors act in the fatty dermal layer of the dermis where PRP is injected to promote collagen and capillary
    growth, which gradually improves the appearance of depression and skin texture.

    The effects last for a long time because your skin is regenerated!

    Because "Available only in Japan." PRPG injections treatment regenerates your skin without using foreign substances, the effects last longer than hyaluronic acid or Botox injections. The effects gradually fade away at the same speed as natural aging but it will change naturally at the same speed as the surrounding area, so you wouldn't feel the difference between the treated and non-treated areas.

  • The Skin Regeneration Effect Lasts more than 3 years! The Skin Regeneration Effect Lasts more than 3 years!

    Authorized by the Ministry of
    Health, Labor and Welfare

    PRPG injections are our original regenerative medicine. Regenerative medicine can only be handled by medical institutions that have been specifically certified by the government.

  • The Skin Regeneration Effect Lasts more than 3 years! The Skin Regeneration Effect Lasts more than 3 years!

    Highle Safe /
    Consideration of Pain

    Because "Available only in Japan." PRPG injections treatment uses your own blood and Fibroblast growth factors (FGF), allergy and rejection reactions are uncommon. We use extra-fine pure needles and nitrous oxide anesthesia to minimize pain during the procedure.

Available 24 hours a day Available 24 hours a day

Inquiry &
Free counseling service

  • Online reservation
  • Instagram
Case StudiesCase Studies
Dark Circles Under The Eyes (One Month After Treatment)
28-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (One Month After Treatment)
27-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (One Month After Treatment)
38-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (One Month After Treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (40 days after treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (One Month After Treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (One Month After Treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (One Month After Treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes (One Month After Treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dark Circles Under The Eyes, Gorgon Line(One Month After Treatment)
38-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Under The Eyes, Gorgon Line
PRP (volume) 1ml each
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
27-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 6ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
28-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 8ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
32-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 8ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
26-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 6ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
32-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 6ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
29-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 4ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
26-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 6ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead
30-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 8ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(One Month After Treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 6ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(56 days after treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead
PRP (volume) 6ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Sloping forehead(35 days after treatment)
28-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Forehead・Temple
PRP (volume) 6ml
Approximate Rates ¥240,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Nascent line(One Month After Treatment)
38-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Nascent Line
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Nascent line(One Month After Treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Nascent Line
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Nascent line(One Month After Treatment)
33-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Nascent Line
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Nascent line(One Month After Treatment)
48-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Nascent Line
PRP (volume) 1ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Wrinkles and indentations on the chin(One Month After Treatment)
26-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Chin
PRP (volume) 2ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dimples on the temples(One Month After Treatment)
32-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Temple
PRP (volume) 4ml
Approximate Rates ¥98,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Dimples on the temples(60 days after treatment)
28-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Temple
PRP (volume) 4ml
Approximate Rates ¥98,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Chin(40 days after treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Chin
PRP (volume) 2ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Wrinkles on the hand(40 days after treatment)
female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Back Of The Hand
PRP (volume) 12ml
Approximate Rates ¥168,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Gorgon Line
32-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Gorgon Line
PRP (volume) 2ml
Approximate Rates ¥89,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Indentations in the cheeks(One Month After Treatment)
38-year-old female
Case Studies
In rare cases, internal bleeding and swelling may occur.
injected area Cheek
PRP (volume) 8ml
Approximate Rates ¥98,000(w/o tax)
In rare cases, internal bleeding and swelling may occur.
Available 24 hours a day Available 24 hours a day

Inquiry &
Free counseling service

  • Online reservation
  • Instagram
Flow of Treatment Flow of Treatment
Treatment can be recieved at
the first visit
  • Counseling1

    Counseling

    Please tell us as much as possible about the condition or area you would like to treat. We will recommend the best treatment for your symptoms.

  • Drawing blood2

    Drawing blood

    The blood is drawn for the preparation of PRP. The amount of blood drawn will vary depending on your request. You may still need to have a blood test before the procedure.

  • PRP preparation3

    PRP preparation

    PRP is extracted from the prepared blood through a centrifuge. The prepared PRP can be viewed by you before the treatment.

  • Treatment4

    Treatment

    The prp is injected into the area where you want to regenerate the skin.

  • Return home5

    Return home

    You can go home immediately after the procedure.

Downtime, post-surgery, side
effects and contraindications

Treatment
Time		 About 1 hour.
Anesthesia Nitrous oxide anesthesia,
anesthesia patches, and topical anesthesia
Postopera-
tive visits		 Unnecessary
Downtime
  • You can wash your face and shower after 30 minutes.
  • Make up can be applied right after the treatment.
  • Swelling may occur around the injected area and last for a few weeks. (The duration varies depending on the treated area.)
  • Internal hemorrhage rarely occurs.
  • Strong pressure on the injected area should be avoided for a month.
Contraindi-
cation
  • Those who have a history of malignant tumors
  • Pregnant or lactating women
  • Those with keloid constitution
Potential
risks		 The injected area might swell for
3-4 days.
Cost Cost
Injected area 1 location Additional charge for 2 or more locations
Nasolabial fold, Wrinkles between the eyebrows, chin, Dark Circles Under The Eyes, Mid cheek groove, marionette lines, wrinkles on the forehead, inner corner of the eye, Wrinkles at the corners of the eyes ¥89,000

¥97,900(tax in)

 ¥35,000

¥38,500(tax in)
Injected area 1 location Additional charge for 2 or more locations
lips,cheeks, Hollowing of the upper eyelids, neck wrinkles, earlobes, nose root, tip of the nose ¥98,000

¥107,800(tax in)

 ¥40,000

¥44,000(tax in)
  • The price is the same regardless of the amount of PRP injected.
  • Since there is a limit to the amount of blood that can be drawn, the area that can be treated at the same time is limited.
  • If you would like a part other than those above, please contact us.
Injected area Pricing
Forehead + Temples ¥240,000

¥264,000(tax in)
Forehead + Temples retouch injection ¥120,000

¥132,000(tax in)

    ＜About retouch injection＞

    ●Only for those who have undergone forehead and temple treatment at our hospital

    ●Limited to the same part

    ●Same price from second time onwards

    ●This amount cannot be used for injections for wrinkles on the forehead or hollows in the temples.

Injected area Pricing
Rejuvenate heart injection ¥260,000

¥286,000(tax in)
Rejuvenate hand (both hands) ¥128,000

¥140,800(tax in)
Rejuvenate hand (both hands) + Sclerotherapy (both hands) ¥210,000

¥231,000(tax in)
Rejuvenate injection elbow
(both arms)		 ¥108,000

¥118,800(tax in)
Rejuvenate injection knee
(both legs)		 ¥108,000

¥118,800(tax in)
Relaxed anesthesia (IV) ¥35,000〜¥65,000

¥38,500〜¥71,500(tax in)

Directions

Pruge Beauty Clinic
Pruge Beauty Clinic

Pruge Beauty Clinic

  • AddressDai2 (the second) Akiyama buiding 4F,
    2-4-18 Konan, Minatoku, Tokyo
    108-0075
  • The nearest
    station exit    A 3-minute walk from the south exit of
    JR
    Shinagawa
    station
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Available 24 hours a day Available 24 hours a day

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